Biography
Dr. Hobart W. Harris is an expert in treating surgical infections, diseases of the pancreas and biliary system and abdominal wall hernias, including pancreas, gallbladder and bile duct cancer, acute and chronic pancreatitis, islet autotransplantation for chronic pancreatitis, complex gallstone disease, intra-abdominal sepsis, serious infections of the skin and soft tissue, and enterocutaneous fistulas. He treats patients with complicated and often life-threatening conditions through the Complex Abdominal Surgery Program. Dr. Harris is also a pioneer and leader in the management and repair of complex ventral (incisional) hernias. Specifically, he is an expert at repairing gigantic ventral hernias, where closure of the defect and reconstructing the abdominal wall requires advanced techniques, such as progressive pneumoperiteum whereby the abdominal wall muscles are first stretched prior to repairing the hernia.
Dr. Harris earned his undergraduate, medical and public health degrees at Harvard University, before completing an internship and residency in general surgery at UCSF. After residency training, he completed a fellowship in Hepatobiliary Surgery at the University of Hong Kong, Queen Mary Hospital before joining the faculty at UCSF in 1994. Harris is a Fellow of the American College of Surgeons and is a member of numerous surgical and scientific societies including the American Surgical Association.
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Education
Institution | Degree | Dept or School | End Date |
---|---|---|---|
Harvard University | M.D. | School of Medicine | 1983 |
University of California, San Francisco | Residency | School of Medicine - Surgery |
Board Certifications
- American Board of Surgery, 1994
Clinical Expertise
Acute Pancreatitis
Bile Duct Injuries
Chronic Pancreatitis
Gall Bladder Disease
Ventral (Incisional) Hernia
Complex Abdominal Surgery
Recurrent Hernia
Laparoscopic Inguinal Hernia Repair
Gastrointestinal Cancer
Gastrointestinal Surgery
Intra-abdominal Sepsis
Pancreas Surgery
Pancreatic Cancer
Soft Tissue Infections
Enterocutaneous Fistula
Hepatobiliary Surgery
Clinical Trials
- A Study of Fibrin Sealant Plus Silver Microparticles to Prevent Incisional Hernias Following Abdominal Surgery (NCT02584153)Related Conditions: Hernia, Ventral Hernia| Start Date: | End Date:
- Related Conditions: Hernia, Ventral Hernia| Start Date: | End Date:
Grants and Funding
- Research Training in Gastrointestinal Surgery | NIH | 1988-07-01 - 2021-06-30 | Role: Principal Investigator
- Complex Ventral Hernia Repair | NIH | 2013-07-15 - 2017-06-30 | Role: Principal Investigator
- Lipoproteins and Microbial Immunity | NIH | 2010-08-15 - 2015-07-31 | Role: Principal Investigator
- Lipoproteins Modulate the Hepatic Response to Endotoxin | NIH | 1999-05-01 - 2010-01-31 | Role: Principal Investigator
- General Clinical Research Center | NIH | 1974-10-01 - 2007-11-30 | Role: Co-Investigator
- CHYLOMICRON REMNANTS &ATHEROSCLEROSIS | NIH | 1988-11-05 - 1900-01-01 | Role: Principal Investigator
Research Narrative
Dr. Harris is Director of the Infection, Injury and Immunity Lab. His research focuses on surgical infections, innate immunity and the management of complex ventral hernias. He is also an innovator, inventor and entrepreneur in the surgical field.
Research Pathways
Publications
- Tertiary lymphoid structures sustain cutaneous B cell activity in hidradenitis suppurativa.| | PubMed
- Quality of life measures and cost analysis of biologic versus synthetic mesh for ventral hernia repair: The Preventing Recurrence in Clean and Contaminated Hernias randomized clinical trial.| | PubMed
- Data Requirement for Animal-Derived Wound Care Devices: Limitations of the 510(k) Regulatory Pathway.| | PubMed
- Feasibility of Gastrografin Use for Adhesive Small Bowel Obstruction in Low-Income Countries.| | PubMed
- Biologic Versus Synthetic Mesh in Ventral Hernia Repair: Participant-Level Analysis of Two Randomized Controlled Trials at Twenty-Four to Thirty-Six Months.| | PubMed
- Tertiary Lymphoid Structures Sustain Cutaneous B cell Activity in Hidradenitis Suppurativa.| | PubMed
- A Novel Polypropylene Mesh (T-Line®) for Abdominal Wall Repair: Early Experience at Three Centers in the United States.| | PubMed
- Expert Consensus for Key Features of Operative Reports of Ventral Hernia.| | PubMed
- Updated guideline for closure of abdominal wall incisions from the European and American Hernia Societies.| | PubMed
- Innovations for Incisional Hernia Prevention.| | PubMed
- Immunopathogenesis of hidradenitis suppurativa and response to anti-TNF-α therapy.| | PubMed
- Cost-Effectiveness Analysis of Inguinal Hernia Repair With Mesh Performed by Surgeons and Medical Doctors in Ghana.| | PubMed
- Early-life inflammation primes a T helper 2 cell-fibroblast niche in skin.| | PubMed
- Layilin Anchors Regulatory T Cells in Skin.| | PubMed
- Burden of Ionizing Radiation in the Diagnosis and Management of Necrotizing Pancreatitis.| | PubMed
- Preventing Recurrence in Clean and Contaminated Hernias Using Biologic Versus Synthetic Mesh in Ventral Hernia Repair: The PRICE Randomized Clinical Trial.| | PubMed
- Enhanced Stress Resilience Training in Surgeons: Iterative Adaptation and Biopsychosocial Effects in 2 Small Randomized Trials.| | PubMed
- Jejunal prolapse and incarceration following feeding tube exchange.| | PubMed
- Immunopathogenesis of hidradenitis suppurativa and response to anti-TNF-α therapy.| | PubMed
- Upper Gastrointestinal Endoscopy in an Academic General Surgical Program: Implications for Acute Care Surgeons.| | PubMed
- Regulatory T cells use arginase 2 to enhance their metabolic fitness in tissues.| | PubMed
- Key factors for implementing mindfulness-based burnout interventions in surgery.| | PubMed
- Integrating Robotic Technology Into Resident Training: Challenges and Recommendations From the Front Lines.| | PubMed
- Outcomes After Inguinal Hernia Repair With Mesh Performed by Medical Doctors and Surgeons in Ghana.| | PubMed
- Practice Patterns and Attitudes of Surgeons on the Use of Prophylactic Mesh to Prevent Parastola Hernia: A Cross-sectional Survey.| | PubMed
- Efficacy of Mindfulness-Based Cognitive Training in Surgery: Additional Analysis of the Mindful Surgeon Pilot Randomized Clinical Trial.| | PubMed
- Comparison of Tumor Regression Grading of Residual Pancreatic Ductal Adenocarcinoma Following Neoadjuvant Chemotherapy Without Radiation: Would Fewer Tier-Stratification Be Favorable Toward Standardization?| | PubMed
- Feasibility of Formal Mindfulness-Based Stress-Resilience Training Among Surgery Interns: A Randomized Clinical Trial.| | PubMed
- Secondary peritonitis: principles of diagnosis and intervention.| | PubMed
- A Coupled Magnetoelastic Strain Sensor Array for Guiding and Monitoring Hernia Repairs.| | PubMed
- Contemporary concepts in hernia prevention: Selected proceedings from the 2017 International Symposium on Prevention of Incisional Hernias.| | PubMed
- Silver microparticles plus fibrin tissue sealant prevents incisional hernias in rats.| | PubMed
- Burnout and Stress Among US Surgery Residents: Psychological Distress and Resilience.| | PubMed
- Impact of surgical intensive care unit interdisciplinary rounds on interprofessional collaboration and quality of care: Mixed qualitative-quantitative study.| | PubMed
- Integrating coupled magnetoelastic sensors onto a flexible hernia mesh for high dynamic range strain measurements.| | PubMed
- Preoperative FOLFIRINOX for borderline resectable pancreatic cancer: Is radiation necessary in the modern era of chemotherapy?| | PubMed
- Postoperative Prophylactic Antibiotic Use following Ventral Hernia Repair with Placement of Surgical Drains Reduces the Postoperative Surgical-Site Infection Rate.| | PubMed
- Towards a full-field strain sensor for guiding hernia repairs.| | PubMed
- Appendicitis within Morgagni Hernia and simultaneous Paraesophageal Hernia.| | PubMed
- Low-dose cyclophosphamide improves survival in a murine treatment model of sepsis.| | PubMed
- A prospective, randomized controlled trial of single-incision laparoscopic vs conventional 3-port laparoscopic appendectomy for treatment of acute appendicitis.| | PubMed
- Memory regulatory T cells reside in human skin.| | PubMed
- Clinical outcomes of biologic mesh: where do we stand?| | PubMed
- Biologic mesh for ventral hernia repair: a cautionary tale.| | PubMed
- Characterizing the global burden of surgical disease: a method to estimate inguinal hernia epidemiology in Ghana.| | PubMed
- Does increased experience with laparoscopic cholecystectomy yield more complex bile duct injuries?| | PubMed
- Heparin protects against septic mortality via apoE-antagonism.| | PubMed
- NKT cells: the culprits of sepsis?| | PubMed
- NKT cells in sepsis.| | PubMed
- Chylomicrons combined with endotoxin moderate microvascular permeability.| | PubMed
- An expanding role for apolipoprotein E in sepsis and inflammation.| | PubMed
- Prospective randomized trial of LC+LCBDE vs ERCP/S+LC for common bile duct stone disease.| | PubMed
- Open incisional hernia repair at an academic tertiary care medical center.| | PubMed
- Enteric fistulas: principles of management.| | PubMed
- Anaphylaxis caused by recurrent hydatid disease.| | PubMed
- Variation in annual volume at a university hospital does not predict mortality for pancreatic resections.| | PubMed
- Predicting strangulated small bowel obstruction: an old problem revisited.| | PubMed
- Apolipoprotein E-mediated immune regulation in sepsis.| | PubMed
- The future of general surgery.| | PubMed
- Actinomycosis mimicking a pancreatic head neoplasm diagnosed by EUS-guided FNA.| | PubMed
- The value of teaching anatomy to medical students.| | PubMed
- Pancreaticoduodenectomy: volume is not associated with outcome within an academic health care system.| | PubMed
- The surgical hospitalist: a new solution for emergency surgical care?| | PubMed
- Randomized, double-blind, placebo-controlled trial of cephalexin for treatment of uncomplicated skin abscesses in a population at risk for community-acquired methicillin-resistant Staphylococcus aureus infection.| | PubMed
- Chylomicron-bound LPS selectively inhibits the hepatocellular response to proinflammatory cytokines.| | PubMed
- The surgical hospitalist: a new model for emergency surgical care.| | PubMed
- Enhancing the mission of academic surgery by promoting scientific writing skills.| | PubMed
- Antibiotic use in the treatment of soft tissue abscesses: a survey of current practice.| | PubMed
- Exporting excellence for Whipple resection to refine the Leapfrog Initiative.| | PubMed
- Inappropriate antibiotic use in soft tissue infections.| | PubMed
- Applying Ockham's razor to pancreatitis prognostication: a four-variable predictive model.| | PubMed
- Statins attenuate sepsis.| | PubMed
- Triglyceride-rich lipoproteins as agents of innate immunity.| | PubMed
- Apolipoprotein E: from Alzheimer's to sepsis.| | PubMed
- Image of the month--quiz case. Traumatic intramuscular cyst of the duodenum.| | PubMed
- Cholecystectomy after endoscopic sphincterotomy for common bile duct stones: is surgery necessary?| | PubMed
- Early nonenhanced abdominal computed tomography can predict mortality in severe acute pancreatitis.| | PubMed
- Heat shock inhibits NF-kB activation in a dose- and time-dependent manner.| | PubMed
- Lipoproteins are protective beyond high-density lipoprotein cholesterol and heart disease.| | PubMed
- The evolution of endoscopy: wireless capsule cameras for the diagnosis of occult gastrointestinal bleeding and inflammatory bowel disease.| | PubMed
- Lipoprotein-bound endotoxin exerts an immunomodulatory effect on hepatocytes through the lipid A domain of LPS.| | PubMed
- An epidemic of methicillin-resistant Staphylococcus aureus soft tissue infections among medically underserved patients.| | PubMed
- Induction of cytokine tolerance requires internalization of Chylomicron-Bound LPS into hepatocytes.| | PubMed
- Gallbladder ascariasis in a patient with severe pancreatitis.| | PubMed
- Induction of cytokine tolerance in rodent hepatocytes by chylomicron-bound LPS is low-density lipoprotein receptor dependent.| | PubMed
- Lipoprotein-bound LPS induces cytokine tolerance in hepatocytes.| | PubMed
- Care of injection drug users with soft tissue infections in San Francisco, California.| | PubMed
- Chylomicron-bound endotoxin selectively inhibits NF-kappaB activation in rat hepatocytes.| | PubMed
- Hepatic endosomal trafficking of lipoprotein-bound endotoxin in rats.| | PubMed
- Endogenous lipoproteins impact the response to endotoxin in humans.| | PubMed
- Necrotizing pancreatitis during pregnancy: a rare cause and review of the literature.| | PubMed
- Extracellular matrix regulates the hepatocellular heat shock response.| | PubMed
- The lipemia of sepsis: triglyceride-rich lipoproteins as agents of innate immunity.| | PubMed
- Diet-induced protection against lipopolysaccharide includes increased hepatic NO production.| | PubMed
- Leukocytosis and free fluid are important indicators of isolated intestinal injury after blunt trauma.| | PubMed
- Obstructive jaundice alters Kupffer cell function independent of bacterial translocation.| | PubMed
- Recurrent pyogenic cholangitis.| | PubMed
- Chylomicrons alter the hepatic distribution and cellular response to endotoxin in rats.| | PubMed
- Changing management of gallstone disease during pregnancy.| | PubMed
- Surgical risk assessment and management in patients with HIV disease.| | PubMed
- Sepsis increases endocytosis of endotoxin into hepatocytes.| | PubMed
- The protective effect of serum lipoproteins against bacterial lipopolysaccharide.| | PubMed
- Chylomicrons enhance endotoxin excretion in bile.| | PubMed
- Chylomicrons alter the fate of endotoxin, decreasing tumor necrosis factor release and preventing death.| | PubMed
- Chylomicrons can inhibit endotoxin activity in vitro.| | PubMed
- Detection of endotoxin in triglyceride-rich lipoproteins in vitro.| | PubMed
- Human very low density lipoproteins and chylomicrons can protect against endotoxin-induced death in mice.| | PubMed
- Saphenous vein bypass to pedal arteries. An aggressive strategy for foot salvage.| | PubMed
- Identification of aortic thrombus by magnetic resonance imaging.| | PubMed
- Particle size distribution of lipoproteins from human atherosclerotic plaque: a preliminary report.| | PubMed