Biography
Hirose's research interests include the induction of immunologic tolerance, immune monitoring and cancer in transplant patients. He has received research grants from the National Kidney Foundation and UCSF School of Medicine.
Hirose earned his medical degree from Vagelos College of Physicians and Surgeons, the medical school of Columbia University. He completed clinical research training at UCSF as a resident in general surgery and a fellow in molecular medicine and transplantation surgery.
Hirose is involved in teaching medical students as well as residents and fellows in surgery. He serves as associate director of UCSF's general surgery residency program.
Education
Institution | Degree | Dept or School | End Date |
---|---|---|---|
University of California | Diversity, Equity, and Inclusion Champion Training | 2019 | |
University of California, San Francisco | Residency | School of Medicine |
Board Certifications
- American Board of Surgery, 1998
Clinical Expertise
Bile Duct Injuries
Bile Duct Strictures
Bile Duct Cancer (Cholangiocarcinoma)
Complex Cancer Resections
Fulminant Hepatic Failure
Hepatitis B
Hepatitis C
Hepatocellular Carcinoma (Liver Cancer)
Kidney Transplantation
Liver Resection
Liver Transplantation
Living Donor Liver Transplantation
Living Donor Kidney Transplantation
Pancreas Transplants
Pediatric Liver Transplantation
Pediatric Kidney Transplantation
Portal Hypertension
Radio Frequency Ablation (RFA)
Surgical Shunts
In the News
Research Narrative
Dr. Hirose's research focus is ischemia-reperfusion injury and potential interventions to ameliorate renal and hepatic I-R injury. His group uses animal models, performs clinical and translational research as well as research on deceased donors. He collaborates with Dr. Claus Niemann, MD from the Dept. Anesthesia and they are co-Directors of the Ischemic Organ Injury Lab.
Research Interests
- Living Donor Liver Transplantation
- Non-melanoma Skin Cancer in Organ Transplant Patients
- Pathogenesis of Focal Segmental Glomerulosclerosis
- Outcomes in Renal Transplant Recipients
- Ischemia Reperfusion Injury in Fatty Livers
- Ischemia-reperfusion Injury in Kidneys and Hyperglycemia
Research Pathways
Publications
- Highly sensitized patients listed for heart after liver transplantation with or without domino.| | PubMed
- Graft choice in pancreatectomy with vascular resection: equivalent safety in selected patients.| | PubMed
- ASO Visual Abstract: Long-Duration Neoadjuvant Therapy with FOLFIRINOX Yields Favorable Outcomes for Patients Who Undergo Surgery for Pancreatic Cancer.| | PubMed
- Long-Duration Neoadjuvant Therapy with FOLFIRINOX Yields Favorable Outcomes for Patients Who Undergo Surgery for Pancreatic Cancer.| | PubMed
- Adjusting for race in metrics of organ procurement organization performance.| | PubMed
- DCD liver transplant in patients with a MELD over 35.| | PubMed
- Community-level social vulnerability and individual socioeconomic status on liver transplant referral outcome.| | PubMed
- Geographic disparities in access to liver transplantation.| | PubMed
- Stakeholders' perspectives on transplant metrics: the 2022 Scientific Registry of Transplant Recipients' consensus conference.| | PubMed
- Time to discard the term "discard".| | PubMed
- OPTN/SRTR 2021 Annual Data Report: COVID-19.| | PubMed
- Number of Local Regional Therapies for Hepatocellular Carcinoma and Peri-Operative Outcomes after Liver Transplantation.| | PubMed
- Toward a better distribution system: it is complicated.| | PubMed
- The Reality of Inadequate Patient Care and the Need for a Global Action Framework in Organ Donation and Transplantation.| | PubMed
- Assessment of Surgeon Performance of Advanced Open Surgical Skills Using a Microskills-Based Novel Curriculum.| | PubMed
- Transplant program evaluations in the middle of the COVID-19 pandemic.| | PubMed
- Toward continuous improvement of Scientific Registry of Transplant Recipients performance reporting: Advances following 2012 consensus conference and future consensus building for 2022 consensus conference.| | PubMed
- Pancreas Transplantation for Type 2 Diabetes: A Systematic Review, Critical Gaps in the Literature, and a Path Forward.| | PubMed
- Surgical complications after living and deceased donor liver transplant: The NSQIP transplant experience.| | PubMed
- Long-term Outcomes Following Kidney and Liver Transplant in Recipients With HIV.| | PubMed
- Toward a more efficient organ placement system (and defeating FOMO).| | PubMed
- International Travel for Liver Transplantation: A Comprehensive Assessment of the Impact on the United States Transplant System.| | PubMed
- Impact of COVID-19 pandemic on the size of US transplant waiting lists.| | PubMed
- Advantages and Limitations of Clinical Scores for Donation After Circulatory Death Liver Transplantation.| | PubMed
- The Impact of Median Model for End-Stage Liver Disease at Transplant Minus 3 National Policy on Waitlist Outcomes in Patients With and Without Hepatocellular Carcinoma.| | PubMed
- Machine Learning Prediction of Liver Allograft Utilization From Deceased Organ Donors Using the National Donor Management Goals Registry.| | PubMed
- The Effect of Acuity Circles on Deceased Donor Transplant and Offer Rates Across Model for End-Stage Liver Disease Scores and Exception Statuses.| | PubMed
- Equity in kidney transplant allocation - North American perspective.| | PubMed
- Standardizing Discharge Opioid Prescriptions in Kidney Transplant Patients Decreases Opioid Usage.| | PubMed
- Understanding the Impact of Pneumonia and Other Complications in Elderly Liver Transplant Recipients: An Analysis of NSQIP Transplant.| | PubMed
- Live Donor Liver Transplantation in the United States: Impact of Share 35 on Live Donor Utilization.| | PubMed
- Mortality among solid organ waitlist candidates during COVID-19 in the United States.| | PubMed
- Setting rules for the sandbox: A response to "Successfully sharing the sandbox: A perspective on combined DCD liver and heart donor procurement".| | PubMed
- Metastatic Donor-derived Malignancies Following Simultaneous Pancreas-kidney Transplant: Three Case Reports and Management Strategies.| | PubMed
- Opioid use prior to liver transplant is associated with increased risk of death after transplant.| | PubMed
- COVID-19 and Abdominal Transplant: A Stepwise Approach to Practice During Pandemic Conditions.| | PubMed
- Contemporary Management of Hepatic Cyst Disease: Techniques and Outcomes at a Tertiary Hepatobiliary Center.| | PubMed
- Early national and center-level changes to kidney transplantation in the United States during the COVID-19 epidemic.| | PubMed
- Implementing an opioid reduction protocol in renal transplant recipients.| | PubMed
- A Virtual Crossmatch-based Strategy Facilitates Sharing of Deceased Donor Kidneys for Highly Sensitized Recipients.| | PubMed
- A model for the institutional adoption of innovative surgical techniques.| | PubMed
- Balancing Efficiency and Fairness in Liver Transplant Access: Tradeoff Curves for the Assessment of Organ Distribution Policies.| | PubMed
- Unfair Advantages for Hepatocellular Carcinoma Patients Listed for Liver Transplant in Short-Wait Regions Following 2015 Hepatocellular Carcinoma Policy Change.| | PubMed
- The Centers for Medicare and Medicaid Services' proposed metrics for recertification of organ procurement organizations: Evaluation by the Scientific Registry of Transplant Recipients.| | PubMed
- The rise and fall of the model for end-stage liver disease score and the need for an optimized machine learning approach for liver allocation.| | PubMed
- Long-term follow-up of beta cell replacement therapy in 10 HIV-infected patients with renal failure secondary to type 1 diabetes mellitus.| | PubMed
- Beyond death and graft survival-Variation in outcomes after kidney transplantation. Results from the NSQIP Transplant beta phase.| | PubMed
- Changes in Simultaneous Liver-kidney Transplant Allocation Policy May Impact Postliver Transplant Outcomes.| | PubMed
- Beyond death and graft survival-Variation in outcomes after liver transplant. Results from the NSQIP transplant beta phase.| | PubMed
- Predictors of low risk for dropout from the liver transplant waiting list for hepatocellular carcinoma in long wait time regions: Implications for organ allocation.| | PubMed
- State-Based Liver Allocation: Is It a Viable Alternative?| | PubMed
- Association of HLA Antigen Mismatch With Risk of Developing Skin Cancer After Solid-Organ Transplant.| | PubMed
- Comparison of Tumor Regression Grading of Residual Pancreatic Ductal Adenocarcinoma Following Neoadjuvant Chemotherapy Without Radiation: Would Fewer Tier-Stratification Be Favorable Toward Standardization?| | PubMed
- Alpha-Fetoprotein Decrease from > 1,000 to < 500 ng/mL in Patients with Hepatocellular Carcinoma Leads to Improved Posttransplant Outcomes.| | PubMed
- Development and validation of an optimized prediction of mortality for candidates awaiting liver transplantation.| | PubMed
- Report of National Kidney Foundation Consensus Conference to Decrease Kidney Discards.| | PubMed
- Increasing Liver Transplantation Wait-List Dropout for Hepatocellular Carcinoma With Widening Geographical Disparities: Implications for Organ Allocation.| | PubMed
- How Good Is Good? Benchmarking and the Quest for Quality Improvement in Liver Transplantation.| | PubMed
- Misdiagnosis of hepatocellular carcinoma in patients receiving no local-regional therapy prior to liver transplant: An analysis of the Organ Procurement and Transplantation Network explant pathology form.| | PubMed
- Defining disparities in liver transplantation: The devil is in the details.| | PubMed
- Liver allocation and distribution: time for a change.| | PubMed
- Predicting Outcomes on the Liver Transplant Waiting List in the United States: Accounting for Large Regional Variation in Organ Availability and Priority Allocation Points.| | PubMed
- Resolving Misconceptions About Liver Allocation and Redistricting Methodology.| | PubMed
- Effect of moderately intense perioperative glucose control on renal allograft function: a pilot randomized controlled trial in renal transplantation.| | PubMed
- Preoperative FOLFIRINOX for borderline resectable pancreatic cancer: Is radiation necessary in the modern era of chemotherapy?| | PubMed
- The impact of broader regional sharing of livers: 2-year results of "Share 35".| | PubMed
- Minimal Transplant Survival Benefit for Hepatocellular Carcinoma: Is it Real or an Overestimation of Waitlist Life Expectancy?| | PubMed
- Impact of a quality improvement project on deceased organ donor management.| | PubMed
- Robust Models Support Redistricting Liver Allocation to Reduce Geographic Disparity.| | PubMed
- Therapeutic Hypothermia in Deceased Organ Donors and Kidney-Graft Function.| | PubMed
- Downstaging of hepatocellular cancer before liver transplant: long-term outcome compared to tumors within Milan criteria.| | PubMed
- Delayed hepatocellular carcinoma model for end-stage liver disease exception score improves disparity in access to liver transplant in the United States.| | PubMed
- Outcomes after liver transplantation for patients with hepatocellular carcinoma and a low risk of dropout from the transplant waiting list.| | PubMed
- Identification of liver transplant candidates with hepatocellular carcinoma and a very low dropout risk: implications for the current organ allocation policy.| | PubMed
- Immunosuppression: Conventions and controversies.| | PubMed
- Peri-operative hyperglycemia is associated with delayed graft function in deceased donor renal transplantation.| | PubMed
- Sorafenib combined with locoregional therapy prior to liver transplantation for hepatocellular carcinoma: an update on a previous case report.| | PubMed
- Director of anesthesiology for liver transplantation: existing practices and recommendations by the United Network for Organ Sharing.| | PubMed
- Native renal function after combined liver-kidney transplant for type 1 hepatorenal syndrome: initial report on the use of postoperative Technetium-99 m-mercaptoacetyltriglycine scans.| | PubMed
- Fitzpatrick skin phototype is an independent predictor of squamous cell carcinoma risk after solid organ transplantation.| | PubMed
- Risk factors for liver transplant waitlist dropout in patients with hepatocellular carcinoma.| | PubMed
- Can we cure cholangiocarcinoma with neoadjuvant chemoradiation and liver transplantation? Time for a multicenter trial.| | PubMed
- Validity of patient skin cancer report among organ transplant recipients.| | PubMed
- Intraoperative hyperglycemia augments ischemia reperfusion injury in renal transplantation: a prospective study.| | PubMed
- HLA-DR matching in organ allocation: balance between waiting time and rejection in pediatric kidney transplantation.| | PubMed
- Novel strategies in immunosuppression: issues in perspective.| | PubMed
- Downstaging of hepatocellular carcinoma prior to liver transplant: is there a role for adjuvant sorafenib in locoregional therapy?| | PubMed
- Donor pre-treatment with everolimus or cyclosporine does not reduce ischaemia-reperfusion injury in a rat kidney transplant model.| | PubMed
- Hepatic surgery at a VA tertiary medical center: lessons learned.| | PubMed
- Induction of intestinal ischemia reperfusion injury by portal vein outflow occlusion in rats.| | PubMed
- Kidney transplantation at UCSF: 8,300 transplants and onward.| | PubMed
- Short passive cooling protects rats during hepatectomy by inducing heat shock proteins and limiting the induction of pro-inflammatory cytokines.| | PubMed
- Acute hyperglycemia worsens hepatic ischemia/reperfusion injury in rats.| | PubMed
- Acute kidney injury during liver transplantation as determined by neutrophil gelatinase-associated lipocalin.| | PubMed
- Predictors associated with terminal renal function in deceased organ donors in the intensive care unit.| | PubMed
- Excellent outcome following down-staging of hepatocellular carcinoma prior to liver transplantation: an intention-to-treat analysis.| | PubMed
- Alterations in the proteome of pulmonary alveolar type II cells in the rat after hepatic ischemia-reperfusion.| | PubMed
- Transient hyperglycemia affects the extent of ischemia-reperfusion-induced renal injury in rats.| | PubMed
- Liver transplantation at UCSF--a 20-year experience.| | PubMed
- Increased severity of renal ischemia-reperfusion injury with venous clamping compared to arterial clamping in a rat model.| | PubMed
- Remote renal injury following partial hepatic ischemia/reperfusion injury in rats.| | PubMed
- Ischemia-reperfusion injury is more severe in older versus young rat livers.| | PubMed
- Immunosuppression: today, tomorrow, and withdrawal.| | PubMed
- Mild hypothermia reduces the inflammatory response and hepatic ischemia/reperfusion injury in rats.| | PubMed
- Mild hypothermia protects obese rats from fulminant hepatic necrosis induced by ischemia-reperfusion.| | PubMed
- Warm ischemia-induced alterations in oxidative and inflammatory proteins in hepatic Kupffer cells in rats.| | PubMed
- Glutamine does not protect against hepatic warm ischemia/reperfusion injury in rats.| | PubMed
- A prospective study on downstaging of hepatocellular carcinoma prior to liver transplantation.| | PubMed
- Ischemic preconditioning improves energy state and transplantation survival in obese Zucker rat livers.| | PubMed
- Rapidly developing nephrocalcinosis in a patient with end-stage liver disease who received a domino liver transplant from a patient with known congenital oxalosis.| | PubMed
- Skin cancer as a contraindication to organ transplantation.| | PubMed
- Metabolic profiling of livers and blood from obese Zucker rats.| | PubMed
- Mild hypothermia provides significant protection against ischemia/reperfusion injury in livers of obese and lean rats.| | PubMed
- BKV in simultaneous pancreas-kidney transplant recipients: a leading cause of renal graft loss in first 2 years post-transplant.| | PubMed
- The influence of portoenterostomy on transplantation for biliary atresia.| | PubMed
- Treatment and outcome of invasive bladder cancer in patients after renal transplantation.| | PubMed
- Antitumor immunity induced by dendritic cell-based vaccination is dependent on interferon-gamma and interleukin-12.| | PubMed
- Prediction of survival after liver retransplantation for late graft failure based on preoperative prognostic scores.| | PubMed
- Kidney and liver transplantation in human immunodeficiency virus-infected patients: a pilot safety and efficacy study.| | PubMed
- CD69 expression on peripheral CD8 T cells correlates with acute rejection in renal transplant recipients.| | PubMed
- Management of lymphoceles after renal transplantation: laparoscopic versus open drainage.| | PubMed
- Successful long-term outcomes using pediatric en bloc kidneys for transplantation.| | PubMed
- Live donor renal transplants using kidneys with arteriographic evidence of mild renovascular disease.| | PubMed
- Pros and cons of using interleukin-2 receptor antibodies in liver transplant recipients.| | PubMed